摘要 |
<p>Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the alpha 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which alpha 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj¦gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.</p> |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
SUZUKI, NOBUYASU;YOSHIMURA, TOSHIHIKO;IZAWA, HIROYUKI;SAGI, KAZUYUKI;MAKINO, SHINGO;NAKANISHI, EIJI;MURATA, MASAHIRO;TSUJI, TAKASHI |