| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for easily and efficiently producing an optically active intermediate useful for producing antimicrobial compounds, and to provide an improved method for producing levofloxacin. SOLUTION: This method for producing the corresponding optically active phenoxypropane derivative in high chemical and optical purity, high optical yield and conversion comprises treating a phenoxyacetone derivative with cells of microorganisms selected from the group consisting of those belonging to the genera Pseudomonas, Kocuria, Rhodococcus, Bevundimonas, Aeromonas, Methylobacterium, Candida, Yarrowia, Sporothrix, Mycobacterium, Leifsonia and Stenotrophomonas, a cultured product thereof or extracted fraction thereof, thus providing the improved method for producing levofloxacin. COPYRIGHT: (C)2003,JPO
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