ANTIINFLAMMATORY COMPOSITION CONTAINING XANTHORRHIZOL

摘要

PURPOSE: A pharmaceutical composition containing xanthorrhizol which inhibits the mutation in the body and induces apoptosis of cancer cells is provided. The xanthorrhizol alleviates or reduces inflammation by inhibiting COX-2 and iNOS activity and the composition containing xanthorrhizol can be used for prevention and treatment of cancer and inflammation. CONSTITUTION: A pharmaceutical composition contains xanthorrhizol of the formula 1 as an active ingredient and additionally a pharmaceutically acceptable carrier or diluent. The xanthorrhizol alleviates or reduces inflammation by inhibiting COX-2 and iNOS activity and inhibits carcinogenesis by increasing quinone reductase activity as detoxification enzyme of carcinogen. The xanthorrhizol is a sesquiterpene-based compound and can be separated from Curcuma xanthorrhiza Roxb.