| 发明名称 |
Recombinant alpha-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| 摘要 |
The present invention provides a recombinant human alpha-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human alpha-L-iduronidase enzyme as well as methods to treat certain genetic disorders including alpha-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
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| 申请公布号 |
US6585971(B1) |
申请公布日期 |
2003.07.01 |
| 申请号 |
US20000711205 |
申请日期 |
2000.11.09 |
| 申请人 |
HARBOR-UCLA RESEARCH AND EDUCATION INSTITUTE |
发明人 |
KAKKIS EMIL D. |
| 分类号 |
C12N15/09;A61K9/08;A61K38/00;A61K38/43;A61K38/47;A61K47/02;A61K47/10;A61K48/00;A61P3/00;A61P19/00;A61P43/00;C12N9/24;C12N9/88;C12N15/56;(IPC1-7):A61K38/43;C12N9/00 |
主分类号 |
C12N15/09 |
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