Substituted quinazoline derivatives, their use and a composition comprising said derivatives

摘要

The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)₂, or NR⁶ where R⁶ is hydrogen or C_1-6alkyl; R⁵ is an optionally substituted 5-membered heteroaromatic ring, R¹, R², R³, R⁴ are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed.