发明名称 Use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the treatment of diabetic neuropathy
摘要 (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulphonyl)amino] pyrimidin-5-yl] (3R, 5S)-3,5-dihydroxyhept-6-enoic acid or a pharmaceutically acceptable salt thereof is used in the manufacture of a medicament to treat diabetic neuropathy optionally with another drug useful for treating diabetes or the complications of diabetes such as insulin, troglitazone, rosiglitazone, pioglitazone, MCC-555, (S)-2-ethoxy-3-[4-(2-{4-methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid, 3-{4-[2-(4-tert-butoxycarbonylaminophenyl)ethoxy]phenyl}-(S)-2-ethoxyp ropanoic acid, glimepiride, glibenclamide, gliclazide, glipizide, gliquidone, tolazamide, metformin, acarbose or repaglinide.
申请公布号 NZ513061(A) 申请公布日期 2003.06.30
申请号 NZ20000513061 申请日期 2000.02.01
申请人 ASTRAZENECA AB;THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 发明人 CAMERON, NORMAN EUGENE;COTTER, MARY ANNE
分类号 A61K45/00;A61K;A61K31/192;A61K31/196;A61K31/22;A61K31/235;A61K31/351;A61K31/40;A61K31/4045;A61K31/4184;A61K31/427;A61K31/4418;A61K31/505;A61K38/28;A61K38/55;A61K45/06;A61P;A61P3/10;A61P13/12;A61P25/28;A61P27/12;A61P43/00;(IPC1-7):A61K31/505;A61K31/365;A61K31/44;A61K31/415 主分类号 A61K45/00
代理机构 代理人
主权项
地址