发明名称 ALQUILACAO ENANTIOSSELECTIVA DE COMPOSTOS TRICICLICOS
摘要 <p>Disclosed is a process for preparing a compound of formula (I) wherein X<1>, X<2>, X<3>, X<4> and X<5> are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having formula (II) wherein X<1>, X<2>, X<3>, X<4> and X<5> are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having formula (V) wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.</p>
申请公布号 PT1131313(E) 申请公布日期 2003.06.30
申请号 PT19990958771T 申请日期 1999.11.18
申请人 SCHERING CORPORATION 发明人 SHEN-CHUN KUO;DONALD HOU;CHARLES F. BERNARD;FRANK XING CHEN;AGNES S. KIM-MEADE;GEORGE G. WU
分类号 C07B53/00;C07B61/00;C07D401/04;C07D401/14;(IPC1-7):C07D401/04 主分类号 C07B53/00
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