PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS

摘要

Disclose herein is a method for making compounds that are useful as caspase inhibitor prodrugs of formula wherein R1 is and optionally substituted group selected from an aliphatic group, aralkyl group, heterocyclylalkyl group or aryl group, and R2 is preferably a P2-P4 moiety of a caspase inhibitor. Key intermediates include the azidolactones with formulae 34 claims