Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers

摘要

Substituted benzenesulfonylureas and -thioureas of formula (I) are disclosed, wherein: R1 is H, methyl or trifluoromethyl; R2 is H, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C4)-alkoxy-, (C1-C6)-alkoxy-(C1-C4)-alkoxy-(C1-C4)-alkoxy-, (C1-C6)-alkylthio, (C1-C6)-fluoroalkoxy or (C1-C6)-fluoroalkyl; E is O or S; X is H, halogen, (C1-C6)-alkyl; Y is a hydrocarbon residue of the formula -(CR32)n- wherein the residue R3 independently of one another are each H or (C1-C2)-alkyl, and n is 1, 2, 3 or 4; and Z is halogen, nitro, (C1-C4)-alkyloxy or (C1-C6)-alkyl; The compounds of formula (I) are useful in the treatment and prophylaxis of dysfunctions of the autonomous nervous system, in particular of vagal dysfunctions, for example in the case of cardiovascular diseases. Furthermore, the use of compounds of formula (I) in combination with beta-receptor blockers and products and pharmaceutical preparations which comprise at least one compound of formula (I) and at least one beta-receptor blocker are also disclosed