| 摘要 |
A compound of formula I and stereo-and optical isomers and racemates and pharmaceutically acceptable salts, solvates and crystalline forms in which A is situated in the ortho, meta or para position and represents -C(R3R4)C(R1R2)COR or -CR3CR1COR wherein: R is hydrogen; -ORa, where Ra represents hydrogen, alkyl, aryl or alkylaryl; -NRaRb, wherein Ra and Rb are the same or different and Ra is as defined above and Rb represents hydrogen, alkyl, aryl, alkylaryl, cyano,-OH, -Oalkyl, -Oaryl, -Oalkylaryl,-CORC or-S02Rd, wherein Rc represents hydrogen, alkyl, aryl or alkylaryl and Rd represents alkyl, aryl or alkylaryl; R1 is alkyl, aryl, alkenyl, alkynyl, cyano; -ORe, wherein Re is alkyl, acyl, aryl or alkylaryl; -O-[CH2]m-ORf,[CH2]m-ORf, wherein Rf represents hydrogen, alkyl, acyl, aryl or alkylaryl and m represents an integer 1-8; -OCONRaRC, wherein Ra and Rc are as defined above; -SRd, wherein Rd is as defined above; -SO2NRaRf, wherein Rf and Ra are as defined above; -SO2ORa, wherein Ra is as defined above; -COORd, wherein Rd is as defined above; R2 is hydrogen, halogen, alkyl, aryl, or alkylaryl; R3 and R4 are the same or different and each represents hydrogen, alkyl, aryl, or alkylaryl, n is an integer 1-6; D is situated in the ortho, meta or para position and represents -OS02Rd, wherein Rd is as defined above; -OCONRfRa, wherein Rf and Ra are as defined above; -NRCCOORd, wherein Rc and Rd are as defined above; -NRCCORa, wherein Rc and Ra are as defined above; -NRCRd, wherein Rc and Rd are as defined above; -NRCSO2Rd, wherein Rc and Rd are as defined above; -NRCCONRaRk, wherein Ra, Rc and Rk are the same or different and each represents hydrogen, alkyl, aryl, or alkylaryl; -NRCCSNRaRk, wherein Ra, Rc and Rk are the same or different and each represents hydrogen, alkyl, aryl or alkylaryl; -S02Rd, wherein Rd is as defined above; -SORd, wherein Rd is as defined above; -SRc, wherein Rc is as defined above; -SO2NRaRf, wherein Rf and Ra are as defined above; -SO2ORa , wherein Ra is as defined above; -CN; -CONRCRa, wherein Rc and Ra are as defined above; D' is situated in the ortho, meta or para position and represents hydrogen, alkyl, acyl, aryl, alkylaryl, halogen, -CN, -NO2, -NRfRb, wherein Rf and Rb are as defined above; -ORf, wherein Rf is as defined above; -OSO2Rd, wherein Rd is as defined above; D" is situated in the ortho, meta or para position and represents hydrogen, alkyl, acyl, aryl, alkylaryl, halogen, -CN, -NO2, -NRfRb wherein Rf and Rb are as defined above; -ORf, wherein Rf is as defined above; -OS02Rd, wherein Rd is as defined above. The compound is useful in the treatment of and hyperglycaemia in non insulin dependent diabetes mellitus and dyslipidaemia. Also described is a process to prepare the compound of formula I.
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