New benzothiazine and benzothiadiazine derivatives useful as Alpha amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulators, for preventing and treating e.g. memory disorders, anxiety and depression

摘要

Benzothiazine and benzothiadiazine derivatives (I) their isomers and salts are new. Benzothiazine and benzothiadiazine derivatives (I) their isomers and salts are new; R1 = aryl or heteroaryl; R2 = H, halogen, or OH; X = O or S; Y = O, S, or NR; R = H or 1-6C alkyl; A = CR4R5, NR4 or it may be N and form a with the adjacent group CHR3 a group of formula (i); m = 1-3; R3 = H, 1-6C alkyl or 3-7C cycloalkyl; R4 = H or 1-6C alkyl; R5 = H or halogen. Provided that: (1) aryl groups are mono or bicyclic and may be substituted by alkyl, alkoxy, perhaloalkyl, perhaloalkoxy, OH, CN, alkyl, mono- or dialkylamino, aminosulfonyl, mono or dialkylaminosulfonyl, or optionally substituted phenyl; and (2) heteroaryl groups may have up to three heteroatoms (O, N, S), may be mono or bicyclic and may be substituted as described for aryl groups. An Independent claim is also included for the preparation of (I).