TREATING VASCULAR DISEASE BY INHIBITING MYELOID DIFFERENTIATION FACTOR 88

摘要

Methods included herein describe the treatment of atherosclerosis and other vascular diseases such as thrombosis, restenosis after angioplasty and/or stenting, and vein/graft disease after bypass surgery, by inhibition of the expression or biologic activity of myeloid differentiation factor 88 (MyD88). Also included is an intravascular device coated with a compound that inhibits MyD88, thereby imparting an improved efficacy to the device. TLR-4 cell signal transduction is at least partially responsible for the manifestation, continuation and/or worsening of atherosclerosis and other forms of vascular disease. The present invention provides several means with which to inhabit this signal transduction pathway by affecting the biological activity of MyD88.