SUBSTITUTED PURINE NUCLEOSIDE LIBRARIES AND COMPOUNDS BY SOLID-PHASE COMBINATORIAL STRATEGIES

摘要

Nucleoside analog libraries are prepared in a combinatorial library approach. In some preferred aspects, library diversity is generated using solid phase-coupled nucleosides in a series of at least two modification reactions, and contemplated libraries and compounds include various 2-C-substituted purines, 3-deoxy/aza-6-substituted purines, substituted 2-thioadenosines, 2-amino-6,8-disubstituted purines, 2,8-disubstituted guanosines, 6-substituted purines, 2,6-disubstituted adenosines, and 6,8-disubstituted adenosines. Particularly preferred compounds include nucleoside analogs generated using contemplated libraries, which may be useful in treatment of various conditions, particularly viral infections and neoplastic diseases.