| 摘要 |
This invention provides a total synthesis of Merrillactone and Merrilactone analogues having the structure formula (I), wherein Z is 0 or >N-X, where X is H, straight or branched substituted or unsubstituted alkyl, alkenyl or alkynyl, or acyl, carbamoyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, amino, alkyl amino, or dialkyl amino; wherein each of R1 and RZ is H or R1 and R2 together are =0; wherein each of R3 and R4 is H or R3 and R4 together are =0; wherein each of R5 and R6 is, independently, H, alkyl, aralkyl, or aryl; wherein each of R7 and R8 is, independently, H or OR14, where R14 is alkyl or -C (O) R15, where R15 is H, -CH2R16, -CHR16R16, - CR16R17R16, -OR16, alkenyl or alkynyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, amino, alkyl amino, or dialkyl amino, wherein each R16 is straight or branched, substituted or unsubstituted alkyl, alkenyl or alkynyl , cycloalkyl, aryl heterocycloalkyl, heteroaryl, aralkyl, or amino; and wherei n R17 is straight or branched, unsubstituted alkyl, alkenyl or alkynyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, or amino, or wherei n R7 and R9 together are >0; wherein each of R9 and Rio is, independently, H, alkyl, OH, or OR13, where R13 is an alkyl, an acyl, or an amide, or R9 and R 10 together are =CH2, or wherein R8 and Rio together are >0; wherein if one of R7 or R8 and one of R9 or R10 is absent, a double bond is for med as indicated by the broken line; and wherein each of Ril and R12 is, independently, H, OH, o r OR13, where R13 is an alkyl, an acyl, or an amide, or R11 and R12 together a re =0, or wherein R12 and R10 together are >0, including intermediates in th e synthesis.
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