发明名称 |
Apparatuses and methods for creating and testing pre-formulations and systems for same |
摘要 |
The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
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申请公布号 |
US2003118078(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
US20020156329 |
申请日期 |
2002.05.24 |
申请人 |
CARLSON ERIC D.;CONG PEIJUN;CHANDLER WILLIAM H.;DESROSIERS PETER J.;DOOLEN ROBERT D.;FREITAG J. CHRISTOPHER |
发明人 |
CARLSON ERIC D.;CONG PEIJUN;CHANDLER WILLIAM H.;DESROSIERS PETER J.;DOOLEN ROBERT D.;FREITAG J. CHRISTOPHER |
分类号 |
G01N21/64;B01J19/00;B01L3/00;B01L3/06;B01L7/00;C07B61/00;C07D209/20;C07D293/00;C40B40/10;C40B60/08;C40B60/14;G01N5/04;G01N13/00;G01N21/23;G01N21/27;G01N21/33;G01N21/35;G01N21/47;G01N21/65;G01N21/78;G01N24/08;G01N25/04;G01N30/88;G01N33/15;G01N33/483;G01N33/50;G01N33/53;G01N33/543;G01N35/02;G01N37/00;(IPC1-7):G01K11/06 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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