发明名称 |
2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines |
摘要 |
Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
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申请公布号 |
US2003119844(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
US20020154482 |
申请日期 |
2002.05.22 |
申请人 |
NEUROGEN CORPORATION |
发明人 |
HUANG JIANHUA;HODGGETTS KEVIN;DOLLER DARIO;GE PING;YAMAGUCHI YASUCHIKA |
分类号 |
G01N33/566;A61K31/00;A61K31/44;A61K31/4439;A61K31/495;A61K31/496;A61K31/4965;A61K31/497;A61K31/505;A61K31/5377;A61K51/04;A61P1/04;A61P25/00;A61P25/22;A61P25/24;A61P43/00;C07D213/74;C07D239/34;C07D241/12;C07D401/04;C07D403/04;C07D405/10;G01N33/58;(IPC1-7):A61K31/497;A61K31/506;C0741/04;C0743/04 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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