COMPOSITIONS, METHODS AND KITS RELATING TO THROMBIN DEGRADATION RESISTANT FIBROBLAST GROWTH FACTOR-1

摘要

The invention relates to novel degradation resistant FGF−1, and methods for producing and using the same. More specifically, the invention relates to identification of a thrombin degradation resistant FGF−1, and a nucleic acid encoding the same. The thrombin degradation resistant FGF−1 can elicit responses that are otherwise typically impeded by degradation of FGF−1 by thrombin. Thrombin degradation resistant FGF−1 is an important molecule for effecting an FGF−1 response that would be otherwise inhibited by thrombin. Thus the present invention provides a powerful therapeutic for diseases or disorders wherein an FGF−1 response can mediate a reduction in the frequency or intensity of a symptom of the disease or disorder but for degradation of FGF−1 before it can effect the response.