This invention relates to a method for identifying maxi-K channel blockers comprising using HEK-293 cells that have been stably transfected with both alpha and beta l subunits of the maxi-K channel and incubated with potassium channel blockers that selectively eliminate the endogenous conductances of the HEK-293 cells. Maxi-K channels are important for controlling a number of physiological processes. They play a role in the regulation of aqueous humor dynamics in the eye. Maxi-K channel blockers are known to reduce intraocular pressure.
申请公布号
WO02060340(A3)
申请公布日期
2003.06.26
申请号
WO2002US02014
申请日期
2002.01.25
申请人
MERCK & CO., INC.;GARCIA, MARIA, L.;SCHMALHOFER, WILLIAM, A.