NUCLEOSIDE LIBRARIES AND COMPOUNDS BY MCC COMBINATORIAL STRATEGIES ON SOLID SUPPORT

摘要

Nucleoside analog libraries and compounds contained herein are prepared in a solid phase combinatorial library approach. In some preferred aspects, diverse heterocyclic bases and/or diverse nucleoside substituents are prepared in a multiple component condensation (MCC), while in other preferred aspects library diversity is generated using solid phase-coupled nucleosides in a series of at least two modification reactions. Particularly preferred compounds include nucleoside analogs generated using contemplated libraries, which may be useful in treatment of various conditions, particularly viral infections and neoplastic diseases.