| 摘要 |
<p>Nucleoside analog libraries are prepared in a combinatorial library approach. In some preferred aspects, diverse heterocyclic bases and/or diverse nucleoside substituents are prepared using solid phase-coupled nucleosides in a series of at least two modification reactions. Particularly preferred compounds include various pyrazolopyrimidine, pyrrolidinopyrimidinone, and benzimidazole nucleoside analogs generated using contemplated libraries, which may be useful in the treatment of various conditions, particularly viral infections and neoplastic diseases.</p> |
