CALCIUM PHOSPHATE PARTICLES AS MUCOSAL ADJUVANTS

摘要

The present invention relates to mucosal immune protection, mucosal vaccine delivery, and mucosal drug delivery. Novel calcium phosphate core particles, particularly nanoparticles are used as vaccine adjuvants and compositions fo r inducing protective mucosal immunity. Methods of inducing an immune response to an antigen by devivering the antigen to a mucosal surface using the particles of this invention are also useful for delivering compositions, suc h as a pharmacologically active agent, to the mucosal surfaces of a patient in need thereof, to methods of delivering such compositions, and to methods of making such particles.