发明名称 |
Vectors for tissue-specific replication |
摘要 |
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.
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申请公布号 |
US2003118570(A1) |
申请公布日期 |
2003.06.26 |
申请号 |
US20020323955 |
申请日期 |
2002.12.19 |
申请人 |
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发明人 |
HALLENBECK PAUL L.;CHANG YUNG-NIEN;CHIANG YAWEN L. |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/44;A61K39/23;A61K39/235;A61K39/245;A61K39/29;A61K48/00;A61P35/00;C12N5/08;C12N5/10;C12N15/861;(IPC1-7):A61K48/00;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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