| 摘要 |
1. A formulation, with controlled release and/or delayed release for oral administering such as enteric coated tablets or caplets, wax or polymer coated tablets or caplets or time-release matrices, or combinations thereof containing a selective reuptake inhibitor (SSRI) as paroxetine a pharmaceutically acceptable salt thereof, characterized in that it is a system for the controlled release of an active substance which is an SSRI, comprising (a) a deposit-core comprising an effective amount of the active substance and having defined geometric form, and (b) a support-platform applied to said deposit-core, wherein said deposit-core contains at least the active substance, and at least one member selected from the group consisting of (1) a polymeric material which swells on contact with water or aqueous liquids and a gellable polymeric material wherein the ratio of the said swellable polymeric material to said gellable polymeric material is in the range 1:9 to 9:1, and (2) a single polymeric material having both swelling and gelling properties, and wherein the support-platform is an elastic support, applied to said deposit-core so that it partially covers the surface of the deposit-core and follows changes due to hydration of the deposit core and is slowly soluble and/or slowly gellable in aqueous fluids. 2. A method of treating and/or preventing the disorders by administering an effective and/or a prophylactic amount of a controlled release or delayed release formulation according to claim 1, to a sufferer in need thereof. 3. Use of a controlled release or delayed release formulation according to claim 1 in the manufacture of a medicament, for treating and/or preventing the disorders. 4. A process for the preparation of a formulation according to any one of claims 1, which comprises combining the constituents thereof in the required proportions. |
