Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
申请公布号
EP1320627(A2)
申请公布日期
2003.06.25
申请号
EP20010918690
申请日期
2001.03.15
申请人
THE JOHNS HOPKINS UNIVERSITY
发明人
FLISS, MAKIKO;SIDRANSKY, DAVID;JEN, JIN;POLYAK, KOMELIA;VOGELSTEIN, BERT;KINZLER, KENNETH, W.