Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices

摘要

The present invention relates to pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices and to medicinal aerosol solution formulation products comprising these actuators. In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators with laser drilled orifices. Moreover, the actuators of the present invention allow the use of solution formulations with a high ethanol content and thus, the use of poorly soluble active ingredients in solution formulations.