发明名称 |
Process for the preparation of optically active amines or salts thereof |
摘要 |
A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): <CHEM> wherein R<1> is typically an unsubstituted or substituted hydrocarbon group; and R<2a> is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): <CHEM> wherein R<3> is an unsubstituted or substituted aryl group; R<4> is an unsubstituted or substituted lower alkyl group; and C<1> is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
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申请公布号 |
EP1321452(A2) |
申请公布日期 |
2003.06.25 |
申请号 |
EP20020026415 |
申请日期 |
2002.11.26 |
申请人 |
DAICEL CHEMICAL INDUSTRIES, LTD. |
发明人 |
TANAKA, HIROKI;PAN, LI RUI;IKURA, KIYOSHI |
分类号 |
C07C209/68;C07B53/00;C07B61/00;C07C209/00;C07C209/26;C07C209/52;C07C209/62;C07C211/03;C07C221/00;C07C249/02;C07C251/16;C07D207/14;C07D207/22;C07D207/34;C07D209/54;(IPC1-7):C07C209/68 |
主分类号 |
C07C209/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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