发明名称 |
Use of des-aspartate angiotensin I for the manufacture of a medicament for the prevention and treatment of atherosclerosis, neointima formation and restenosis |
摘要 |
<p>The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-IIe-His-Pro-Phe-His-Leu) as an anti-neointima and anti-arteriosclerotic agent. The compound, given intravenously attenuates the development of neointima formation in balloon catheter-injured carotid arteries of Sprague Dawley rats. The anti-neointima action was dose-dependent and the maximum effect was obtained with a dose of 10 pmoles/day given 2 days pre- and 13 days post-balloon catheterization. When given orally on a chronic basis at a dose of 0.9 mg/kg/day for 47 weeks, the compound significantly attenuates the development of arteriosclerosis in the spontaneously hypertensive rats. The anti-arteriosclerotic action was not blood pressure dependent.</p> |
申请公布号 |
EP0914828(B1) |
申请公布日期 |
2003.06.25 |
申请号 |
EP19980308615 |
申请日期 |
1998.10.21 |
申请人 |
NATIONAL UNIVERSITY OF SINGAPORE |
发明人 |
SIM, MENG KWOON |
分类号 |
A61K38/00;A61K31/00;A61K38/08;A61P9/00;A61P9/10;A61P43/00;C07K7/14;(IPC1-7):A61K38/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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