3,4-DIHYDRO-1H-NAPHTHALENE DERIVATIVE EXCELLENT IN SELECTIVITY AS CYCLOOXYGENASE-2 INHIBITOR

摘要

PROBLEM TO BE SOLVED: To obtain a new compound having selectively inhibiting activity to cyclooxygenase-2. SOLUTION: The 3,4-dihydro-1H-naphthalene derivative [e.g. (E)-1-(4- methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one or 1-(4- methanesulfonyl-phenyl)-4,5-dihydronaphtho[2,1-C]isooxazole] is expressed by general formula (1) or (2). COPYRIGHT: (C)2003,JPO