发明名称 Substitute 1-(piperidin-4-yl)-3-(aryl)-isothioureas, their preparation and therapeutic use
摘要 The invention concerns compounds of formula (I) wherein: R1 and R2, identical or different, represent a saturated or unsaturated alkyl radical, branched or not and containing 1 to 7 carbon atoms; R3 to R8, identical or different, represent a hydrogen, an alkyl branched or not and containing 1 to 5 carbon atoms, an acyloxy, branched or not and containing 1 to 5 carbon atoms, a halogeno, nitro, hydroxy, acyl or alkoxy group containing 1 to 5 carbon atoms, a dialkylamino group containing 1 to 5 carbon atoms, a trifluoromethyl or trifluoro methoxyl group; Z represents an oxygen or sulphur atom or methylene; m represents an integer between 0 and 4 inclusively; n represents an integer between 2 and 7 inclusively; and their pure enantiomers and mixtures, the therapeutically acceptable mineral or organic salts of the compounds of formula (I) and their possible hydrates.
申请公布号 US6583159(B1) 申请公布日期 2003.06.24
申请号 US20010889811 申请日期 2001.07.20
申请人 PIERRE FABRE MEDICAMENT 发明人 PATOISEAU JEAN-FRANCOIS;RIEU JEAN-PIERRE;JOHN GARETH;LEGRAND BRUNO;VERSCHEURE YVAN
分类号 A61K31/4468;A61P9/00;A61P9/04;A61P9/08;A61P9/10;A61P9/12;A61P25/06;A61P25/08;A61P29/02;C07D211/58;(IPC1-7):A61K31/445;C07D211/68 主分类号 A61K31/4468
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