发明名称 |
SPECIFICALLY TARGETED CATALYTIC ANTAGONISTS AND USES THEREOF. |
摘要 |
<p>The invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.</p> |
申请公布号 |
MXPA01010896(A) |
申请公布日期 |
2003.06.24 |
申请号 |
MX2001PA10896 |
申请日期 |
2000.04.21 |
申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
BOTT, RICHARD, R. |
分类号 |
C12N9/50;A45C15/06;A61K38/43;A61K38/55;A61K45/00;A61K47/48;A61P3/06;A61P3/10;A61P5/26;A61P5/28;A61P5/30;A61P7/02;A61P9/06;A61P9/10;A61P9/12;A61P11/02;A61P11/08;A61P21/02;A61P25/04;A61P25/08;A61P25/16;A61P25/18;A61P25/24;A61P29/00;A61P31/12;A61P43/00;C12N9/54;G08B5/00 |
主分类号 |
C12N9/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|