CYCLIC AMIDE COMPOUND AND ITS PHARMACEUTICAL APPLICATION

摘要

PROBLEM TO BE SOLVED: To provide a cyclic amide compound capable of being used for a pharmaceutical which is useful as a cytoprotective agent excellent in inhibiting apoptosis.

SOLUTION: This cyclic amide compound is expressed by the general formula (I): A-B-CO2R5[A is a group selected from the formulae (A-1) to (A-4); B is a 1-10C alkylene or a 3-10C alkenylene; R1is H, a 1-6C alkyl or an aryl, R2is H, a 1-6C alkyl, an aryl or hydroxy, provided that R1and R2are not allowed to be H at the same time; R3and R4are identical to or different from each other, and each H, a 1-6C alkyl, an aralkyl, hydroxy, a 1-6C alkoxy, a halogen, nitro, amino, azido or the like; and R5is H, a 1-6C alkyl or an aralkyl]. The compound, its pharmaceutically acceptable salt or its optical isomer is used for the pharmaceutical.

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