Fremgangsmate for fremstilling av det anticholinerge middel tiotropiumbromid
摘要
Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide.
申请公布号
NO20032827(A)
申请公布日期
2003.06.20
申请号
NO20030002827
申请日期
2003.06.20
申请人
BOEHRINGER INGELHEIM PHARMA GMBH & CO KG
发明人
BANHOLZER, ROLF;BROEDER, WOLFGANG;GRAULICH, MANFRED;LUETTKE, SVEN;MATHES, ANDREAS;MEISSNER, HELMUT;SPECHT, PETER