发明名称 COMPOSITIONS COMPRISING EPOTHILONES AND THEIR USE FOR THE TREATMENT OF CARCINOID SYNDROME
摘要 Use of a compound of formula (I) wherein A represents O or NRN, wherein RN i s hydrogen or lower alkyl, R is hydrogen or lower alkyl, R' is methyl, methoxy , ethoxy, amino, methylamino, dimethylamino, aminomethyl or methylthio, and Z is O or a bond, or a pharmaceutically acceptable salt thereof, alone or in combination with at least one compound selected from the group consisting of somatostatin or a synthetic derivative thereof, interferon- 5-fluorouracil, doxorubicin, cyclophosphamide, streptozotocin and a standard anti-diarrheal, for the preparation of a medicament for the treatment of carcinoid syndrome or at least one neuroendocrine tumor; a method of treating a warm-blooded anima l, having carcinoid syndrome and/or at least one neuroendocrine tumor; a combination comprising a compound formula I as defined above and at least on e compound selected from the group provided above; and to a commercial package comprising said combination.
申请公布号 CA2468994(A1) 申请公布日期 2003.06.19
申请号 CA20022468994 申请日期 2002.12.12
申请人 NOVARTIS AG 发明人 RUBIN, ERIC HOWARD;ROTHERMEL, JOHN DAVID
分类号 A61J1/14;A61K31/427;A61K31/513;A61K31/675;A61K31/7008;A61K31/704;A61K38/16;A61K38/21;A61K45/00;A61K45/06;A61P35/00;A61P43/00;C07D493/04;(IPC1-7):A61K31/427;A61K31/700 主分类号 A61J1/14
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