发明名称 |
PYRIMIDINE-BASED COMPOUNDS USEFUL AS GSK-3 INHIBITORS |
摘要 |
The present invention provides a compound of formula (I): (I), or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders, such as diabetes, cancer, stroke and Alzheimer's disease.
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申请公布号 |
WO03049739(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
WO2002US39190 |
申请日期 |
2002.12.09 |
申请人 |
VERTEX PHARMACEUTICALS, INC.;CHOQUETTE, DEBORAH;DAVIES, ROBERT, J.;WANNAMAKER, MARION, W. |
发明人 |
CHOQUETTE, DEBORAH;DAVIES, ROBERT, J.;WANNAMAKER, MARION, W. |
分类号 |
A61K31/506;A61K31/517;A61K31/519;A61K45/00;A61P3/00;A61P3/10;A61P9/00;A61P9/10;A61P11/06;A61P17/14;A61P25/00;A61P25/14;A61P25/16;A61P25/18;A61P25/28;A61P29/00;A61P35/00;A61P37/02;A61P37/08;A61P43/00;C07D239/94;C07D401/12;C07D401/14;C07D403/12;C07D405/14;C07D409/12;C07D409/14;C07D413/12;C07D417/12;C07D471/04;C07D475/10;C07D487/04;C07D495/04;(IPC1-7):A61K31/506;C07D401/04;C07D409/04;C07D475/00 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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