摘要 |
The invention relates to a method for determining reversible or irreversible physiological side-effects of a substance whereby said method comprises the following steps: a) preparation of a sample treated with the substance, preferably comprising a single cell or several cells in a cell structure or an organ, b) determination of cellular and/or sub-cellular patterns from regional localisations and co-localisations of at least two different molecules, in particular proteins, RNA molecules, or DNA segments, in at least one sub-population of cells, c) comparison of the pattern obtained in step b) with patterns from an untreated control sample and d) determination of a physiological side-effect of the substance by means of various patterns for a treated sample in comparison with an untreated sample. |
申请人 |
EVOTEC OAI AG;EVOTEC TECHNOLOGIES GMBH;HENCO, KARSTEN;JESSEN, TIMM;KUPPER, JUERGEN;GREINER, ERICH;GUENTHER, ROLF |
发明人 |
HENCO, KARSTEN;JESSEN, TIMM;KUPPER, JUERGEN;GREINER, ERICH;GUENTHER, ROLF |