发明名称 |
METHODS OF THERAPY FOR NON-HODGKIN'S LYMPHOMA |
摘要 |
Methods for treating a human with lymphoma using a combination of interleukin- 2 and at least one anti-CD20 antibody are provided. These therapeutic agents are administered as two separate pharmaceutical compositions, one containing IL-2, the other containing at least one anti-CD20 antibody, according to a dosing regimen. Administering of these two therapeutic agents together potentiates the effectiveness of either agent alone, resulting in a positive therapeutic response that is improved with respect to that observed with either agent alone. The therapeutic effects of these agents can be achieved using lower dosages of IL-2, thereby lessening the toxicity of prolonged IL-2 administration and the potential for tumor escape.
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申请公布号 |
CA2469045(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
CA20022469045 |
申请日期 |
2002.12.06 |
申请人 |
CHIRON CORPORATION |
发明人 |
HURST, DEBORAH;WOLIN, MAURICE J.;MILAN, SANDRA |
分类号 |
A61K38/00;A61K39/395;A61P7/00;A61P35/00;C07K16/28;(IPC1-7):A61K39/395;A61K38/20 |
主分类号 |
A61K38/00 |
代理机构 |
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