发明名称 |
Antagonists of HMG1 for treating inflammatory conditions |
摘要 |
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.
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申请公布号 |
US2003113323(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
US20020242056 |
申请日期 |
2002.09.11 |
申请人 |
NORTH SHORE - LONG ISLAND JEWISH RESEARCH INSTITUTE |
发明人 |
TRACEY KEVIN J.;WANG HAICHAO |
分类号 |
G01N33/50;A61K31/70;A61K38/00;A61K39/395;A61K45/00;A61K45/06;A61K48/00;A61P3/04;A61P29/00;A61P31/04;A61P43/00;C07K16/18;G01N33/15;G01N33/68;(IPC1-7):A61K39/395 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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