发明名称 |
PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES |
摘要 |
The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R1 and R2 independently each stands for C1-4-alkyl or together form C2-6-alkylene) with hydrazine or a hydrate or salt thereof formed with an inorganic or organic acid. 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of the Formula I is a known anxiolytic agent. The invention also relates to new intermediates and a process for the preparation thereof. |
申请公布号 |
WO03050092(A2) |
申请公布日期 |
2003.06.19 |
申请号 |
WO2002HU00141 |
申请日期 |
2002.12.12 |
申请人 |
EGIS GYOGYSZERGYAR RT.;MOLNARNE SAMU, ERIKA;SIMIG, GYULA;VAGO, PAL;GREFF, ZOLTAN |
发明人 |
MOLNARNE SAMU, ERIKA;SIMIG, GYULA;VAGO, PAL;GREFF, ZOLTAN |
分类号 |
C07C45/59;C07C49/84;C07D243/02;C07D243/04;C07D317/22;C07D317/26 |
主分类号 |
C07C45/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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