发明名称 |
Method of identifying modulators of presenilin |
摘要 |
A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and the use thereof in the treatment of Alzheimer's disease.
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申请公布号 |
US2003113811(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
US20020221254 |
申请日期 |
2002.11.07 |
申请人 |
HALE RICHARD STEPHEN;ROWLEY ADELE;BLACKSTOCK WALTER |
发明人 |
HALE RICHARD STEPHEN;ROWLEY ADELE;BLACKSTOCK WALTER |
分类号 |
C07K14/47;C12N5/08;G01N33/68;(IPC1-7):G01N33/53;G01N33/567;C12N9/64;C12P21/02 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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