发明名称 |
Tetrahydroindolone and purine derivatives linked to arylpiperazines |
摘要 |
Pharmaceutical composite compositions comprising tetrahydroindolones linked to arylpiperazines and derivatives thereof are disclosed. Specifically, composite compositions useful in treating anti-psychotic disorders are disclosed. The composite compositions disclosed herein can effectively ameliorate symptoms and treat psychotic disorders without causing a decrease in cognitive function. Generally, the composite compounds consist of two moieties, moiety A and B in which a tetrahydroindolone comprises a moiety A linked through a linker L to a moiety B, where B is an arylpiperazinyl moiety. The composite compound provides anti-psychotic actively by interaction with GABA, seratoninne and dopamine receptors. The composite molecules with the combined activities will provide treat psychiatric and neurological diseases without cognitive impairment.
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申请公布号 |
US2003114463(A1) |
申请公布日期 |
2003.06.19 |
申请号 |
US20020209451 |
申请日期 |
2002.07.30 |
申请人 |
FICK DAVID B.;FOREMAN MARK M.;GLASKY ALVIN J.;HELTON DAVID R. |
发明人 |
FICK DAVID B.;FOREMAN MARK M.;GLASKY ALVIN J.;HELTON DAVID R. |
分类号 |
A61K31/496;A61K31/506;C07D209/08;C07D209/88;C07D403/12;C07D403/14;C07D413/12;C07D417/12;(IPC1-7):A61K31/496 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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