CRYSTALLIZED CYTOPLASMIC TIE2 RECEPTOR TYROSINE KINASE DOMAIN AND METHOD OF DETERMINING AND DESIGNING MODULATORS OF THE SAME

摘要

A solved three-dimensional crystal structure of a cytoplasmic Tie2 receptor tyrosine kinase domain is disclosed, along with four crystal forms of the cytoplasmic Tie2 receptor tyrosine kinase domain. The crystal forms include non- and monophosphorylated forms of the cytoplasmic Tie2 receptor tyrosine kinase domain. Methods of designing modulators of the biological activity of the cytoplasmic Tie2 receptor tyrosine kinase domain are also disclosed.