发明名称 |
GESTEIGERTE BILDUNG VON TRIPLE- UND DOPPELHELICES AUS OLIGOMEREN MIT MODIFIZIERTEN PYRIMIDINEN |
摘要 |
<p>An oligomer comprising at least two nucleomonomers and pharmaceutically acceptable salts thereof wherein at least one of said nucleomonomers comprises a base of formula (1) or (2): <CHEM> wherein each X is independently O or S; R<2> is a group comprising at least one pi bond connected to the carbon atom attached to the base; Pr is (H)2 or a protecting group; with the proviso that when at least one of said nucleomonomers of said oligomer comprises deoxyuridine 5-substituted by vinyl, 1-butenyl, 1-pentenyl, 1-hexenyl, 1-heptenyl, 1-octenyl, 1-propynyl, 1-butynyl, 1-hexynyl, 1-heptynyl, or 1-octynyl, then the remainder of the nucleomonomers comprising said oligomer are not solely comprised of phosphodiester linked 2'-deoxyadenosine, 2'deoxyguanosine, 2'-deoxycytidine, thymidine or a combination thereof; and wherein said oligomer includes at least one unit having one of thirteen specific formulas. <IMAGE> <IMAGE></p> |
申请公布号 |
DE69232816(T2) |
申请公布日期 |
2003.06.18 |
申请号 |
DE1992632816T |
申请日期 |
1992.11.24 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
FROEHLER, BRIAN;WAGNER, RICK;MATTEUCCI, MARK;JONES, ROBERT J.;GUTIERREZ, ARNOLD J.;PUDLO, JEFF |
分类号 |
A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K48/00;C07H19/00;C07H19/06;C07H19/067;C07H19/073;C07H19/10;C07H19/20;C07H21/00;C07H21/02;C07H21/04;C12N15/09;C12Q1/68;(IPC1-7):A61K48/00;C07H19/09;C07H19/16;C07H19/167;C07H19/19;C07H19/173 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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