Compounds for treating disorder of eyeground detachment

摘要

The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a¹=a²-a³=a⁴- is a bivalent radical wherein one or two of a¹ to a⁴ are nitrogen and the remaining a¹ to a⁴ are -CH-; -Z¹-Z²- is a bivalent radical; -A- is a bivalent radical of formula -N(R⁶)-Alk²- or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms; R¹, R² and R³ are each independently selected from hydrogen, C_1-6alkyl, hydroxy, halo and the like; Alk¹ and Alk² are optionally substituted C_1-6alkanediyl; R⁵ is a radical of formula wherein n is 1 or 2; p¹ is 0, and p² is 1 or 2; or p¹ is 1 or 2, and p² is 0; X is oxygen, sulfur or -NR⁹; Y² is oxygen or sulfur; R⁷ is hydrogen, C_1-6alkyl, C_3-6cycloalkyl, phenyl or phenylmethyl; R⁸ is C_1-6alkyl, C_3-6cycloalkyl phenyl or phenylmethyl; R⁹ is cyano, C_1-6alkyl, C_3-6cycloalkyl, C_1-6alkyloxycarbonyl or aminocarbonyl; R¹⁰ is hydrogen or C_1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to disturbed fundic accomodation.