| 摘要 |
The chiral catalyst of general structure 1, or its enantiomer is prepared by treating the corresponding N-carboxy anhydride of structure 2, with an aryl metal, especially a phenyl metal such as an aryl magnesium halide, aryl lithium, aryl zinc or aryl cesium, to form a 1,1-diaryl- methanol of structure followed by treatment with a compound of structure, 4 the catalyst, wherein R is aromatic, is novel and in some cases superior to the catalyst wherein R is alkyl or aralkyl in directing the chirality of borane-dimethyl sulfide reductions of ketones to secondary alcohols.
|
