TRANSDERMAL DRUG DELIVERY SYSTEM OF STRYCHNINE, BRUCINE, SECURININE AND THEIR SALTS

摘要

Strychnine, brucine (A) and securinine (B) are a group of natural drugs for central excitation. Because their oral dose or injection dose is close to th e half lethal dose, the drugs, with a great toxic side effect, may be lethal i f improperly used. The invention is characterized by using the transdermal dru g delivery system as a substitute for the oral or injection dosage form to directly act on the local nervous system through the skin, avoiding the toxi c side effect caused by drugs directly entering the blood circulating system. The dose through cutaneous absorption is far lower than the oral or injectio n dose, so it has a much higher safety and a longer acting effect. The transdermal drug delivery system is useful for the treatment of central or peripheral neural paralysis and other nervous system related diseases.