EFFECTORS OF INNATE IMMUNITY

摘要

A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibite d by a peptide is described. A method of identifying a pattern of polynucleoti de expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbes or microbial components in the presence or absence of a peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absen ce of the peptide, wherein the pattern in the presence of the peptide represent s inhibition of an inflammatory or septic response. Also included are compound s and agents identified by the methods of the invention. In another aspect, th e invention provides methods and compounds for enhancing innate immunity in a subject.