| 摘要 |
The present invention concerns the base-catalysed C3-C5 ring expansion of cyclopropanes to cyclopentenols. A process for the production of cyclopentenols (2) from cyclopropanes characterized by the steps of reacting a cyclopropane of the type (1) together with a base in the presence of tetrahydrofuran, according to Scheme 1, wherein R1, R2 and R3 may be the same or different and are each a hydrogen atom, an alkyl radical, an alkenyl radical, an allynyl radical, a cycloalkyl radical, an aralkyl radical, an aryl radical, an alkoxy radical, alkenyloxy radical, an alkoxy carbonyl radical, alkenyloxycarbonyl radical, alkylthio radical, or alkenylthio radical; Formula (1),(2). The process of the invention produces cyclopentenols in high yield and excellent diastereoselectivity.
|
