发明名称 |
MINOR HISTOCOMPATIBILITY ANTIGEN HA-1: TARGET ANTIGEN FOR IMMUNOTHERAPY OF TUMORS |
摘要 |
Allogeneic stem cell transplants (SCT) can induce curative Graft versus Tumor (GvT) reactivities in patients with hematological malignancies. The GvT reaction is mainly mediated by allo immune donor T-cells specific for polymorphic minor Histocompatibility antigens (mHags). Among these, the mHag HA-1 was found to be restricted to the hematopoietic system. Here we report the expression of HA-1 by non-hematopoietic tumor cells. While absent in normal epithelial cells, tumor cells and tumor cell lines particularly from epithelial origin, also express HA-1 and are recognized by HA-1 cytotoxic T cells. The invention provides, among others, means and methods for HA-1 specific immunotherapy for HA-1 positive patients with non-hematopoietic tumor cells.
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申请公布号 |
CA2469104(A1) |
申请公布日期 |
2003.06.12 |
申请号 |
CA20022469104 |
申请日期 |
2002.12.05 |
申请人 |
ACADEMISCH ZIEKENHUIS LEIDEN |
发明人 |
GOULMY, ELSA AFRA JULIA MARIA |
分类号 |
C12Q1/02;A61K35/14;A61K35/26;A61K35/28;A61K39/00;A61K39/395;A61K45/00;A61P35/00;C12N5/06;C12N5/08;G01N33/50;(IPC1-7):A61K35/14 |
主分类号 |
C12Q1/02 |
代理机构 |
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