发明名称 |
NUCLEOTIDE ANALOGUES AND THEIR USE FOR NUCLEIC ACID SEQUENCING |
摘要 |
The invention relates to nucleosides comprising a reporter moiety which also functions to limit polymerase activity, characterised in that the reporter moiety is attached to the nucleoside through a linkage group cleavable by a hydrolase enzyme wherein the hydrolase enzyme is selected from the group consisting of esterases, phosphatases, peptidases, penicillin amidases, glycosidases and phosphorylases.
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申请公布号 |
CA2468432(A1) |
申请公布日期 |
2003.06.12 |
申请号 |
CA20022468432 |
申请日期 |
2002.11.28 |
申请人 |
AMERSHAM BIOSCIENCES UK LIMITED |
发明人 |
PICKERING, LEA;SIMMONDS, ADRIAN;JOHNSON, KARIN SOFIA HELENA;ODEDRA, RAJ |
分类号 |
C12N15/09;C07H19/04;C07H19/06;C07H19/10;C07K7/06;C07K7/08;C07K14/00;C09B11/08;C12Q1/34;C12Q1/68;(IPC1-7):C07H19/00;C07K1/107;C07K1/13;C09B1/36 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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