发明名称 |
ENZYME ACTIVITY PROFILES |
摘要 |
Methods and compositions are provided for evaluating cellular status related to neoplasia. Affinity based probes, particularly having fluorophosphonates as a reactive functionality, are employed that react with a family of enzymes having a common catalytic activity, particularly serine/threonine hydrolases. The probe(s) are combined with the cell components and resulting conjugates are characterized, where the profile of reaction indicates cellular status. A novel serine/threonine hydrolase enzyme is provided.
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申请公布号 |
CA2468457(A1) |
申请公布日期 |
2003.06.12 |
申请号 |
CA20022468457 |
申请日期 |
2002.11.25 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
JESSANI, NADIM;CRAVATT, BENJAMIN F.;LIU, YONGSHENG |
分类号 |
C12N9/64;C12Q1/34;G01N33/574;(IPC1-7):G01N33/574 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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